Over 50% of the value of the company is AWS-maybe 65% AWS generates approx 28.7b and earns 10.5(quarter) Azure generates about 24.5b(less than AWS) but also earns 10.5b Similar money makers similar growth. Msft earns significantly more money overall-circa 50%+ more.

The drug cost > $1B to develop so the price (in the US $3.1M) needs to recover this cost and make a profit. Sickle Cell disease is a terrible illness(genetic) often leading to poor quality of life and shortened life expectancy . Many who suffer from it have regular hospitalisation so you need to factor in the large cost over a number of years vs the upfront cost now coupled with the pain and suffering. The reality is, you've read the headline. They will probably only process a handful of patients a year-there will be a budget. Vertex is not like most drug companies. Their charter is to work in the field of transformative medicines. Medicines that improve healthcare outcomes through discovery and technology. The hard stuff.

Just to add to Adams description and detail, the name is an indicator of your intention for access to the funds. If you intend to take it all, or a big chunk at a given date in the future, you may choose withdrawal, as you intend to withdraw the funds, and so we progress to a defensive position to stabilise the funds ready for withdrawal. If you intend to access the funds in chunks over time or draw an income, then you may chose income. In this case we look to stabilise a proportion of the funds ready for you to draw as income while allowing the rest to continue to seek growth ready to be accessed at a later date

Thanks. I did yesterday. Will wait or try to call. Thanks

Thanks for the super quick response Adam

Thanks Nik. Seen your email and will wait for the other info. Jersey / off shore is a 2026 thing anyway so plenty of time to plan.

@Adam-Kay Thanks, the immediate problem (in my mind) has been resolved. It's now a different problem, which I trust that Nik is resolving off line. Thanks for lowering my blood pressure with the reassurances about the legitimacy of the e-mail. That was my main concern. G

Hi, Our MM product is very short duration, something like 30 days or less on average so yes. The choppy US market is due to their economy being too strong for the feds liking, as it relates to labour markets and the effect on inflation. We are not talking raging inflation either, just a bit higher than ideal. Corporate earnings have never been better. Interest rates are not even that high. We aren't going back to Covid rates nor have higher rates had any real impact on company earnings.

Hi-it was 45%

I'll second that - good video. Thanks for the link.

Email sent to Nik

Hi Alan Drop me a message at nik.burrows@cobensdirect.co.uk and we can take a look at your position and run through the considerations and options that are relevant to you. Cheers Nik

Thank you Nik and Adam for the clarifications on this subject which hopefully will be helpful to others as well. I have funds in GIA which, between my OH and myself, we may not spend all in our lifetime so would look to leave this to our son in the future. It's a fine balancing act between whether to annually make withdrawals to fund the £20,000 ISA allowance or just withdraw up to the piddly £3000 annual gains allowance (e.g. £15,000 withdrawal if gains are 25% - £12,000 capital + £3000 gain). This saves the hassle of doing a tax return since my pension is PAYE so HMRC adjusts my allowance for interest income annually. Who knows, the govt may change this in future but it would seem harsh to pay gains tax followed by IHT.

We will publish something at the year end, given we are so close now. The file Nik refers to is model performance which will vary from actual portfolio performance because it is calculated month to month based on the model weights whereas in reality the daily real performance uses actual moving weights.. In a rising market it will understate the growth by 1-3%. Performance from the top is Tech, Lifestyle Growth, IM 100, Equity. The same applies to FX, month to month is not the same as daily because again, the compounding effect can either amplify or offset the overall monthly growth rate depending on the direction and magnitude on a daily basis. You also have what is called the 'Base Effect' where daily fx moves are relative to the prior day whilst monthly moves compare longer periods. When I state returns, they are actual portfolio returns. The Fact sheets use a point to point monthly performance. Hope that makes sense . The fact sheets(to November) are here near the bottom of the page https://www.cobensdirect.co.uk/literature-library

You aren't wrong O! How can the West compete when, for example, we have min wages/conditions, limits on fossil fuel use and regulations which others may even sign up to but simple ignore them. It's not a level playing field. We could go on however this is a great job for DT to get stuck into And fishing vessels that catch more fibre optic cables than fish

@uk66fastback If you can send me a message, nik.burrows@cobensdirect.co.uk i will take a look for you Cheers Nik

Minor update: remember that token £1 which I moved to Schwab's UK bank account? It arrived back in our UK bank account yesterday, with a message saying something like "Transaction bounced". I guess something went wrong somewhere so I'll chalk this one up as 'one of those things' and have another go (perhaps). Perhaps with £100 this time, which is hopefully enough not to get lost. Thanks for your help.

Earlier week at the Open AI summit, OpenAI's CEO Sam Altman said their next advancement(Model) released in 2025 will be more disruptive than most people expect. 'The industry will see the first examples of AGI in 2025 and will use different tools to achieve complete it. Alman added that initially the impact on humanity will be minimal but in time will become intense. 'In 2025 we will have systems that people will say 'wow, this changes what I expected'. Altman added that in time AGI will bring significant human job displacement. It will be transformative to economies.

Hi Adam, I just tried it again and it's gone through, so no idea what was causing the issue

Thanks for the confirmation. It works just as I thought. Better to ask to confirm than just assume I'm correct. A small mistake can make a big difference.